Crosstalk between Estrogen Signaling and Breast Cancer Metabolism.
Trends Endocrinol Metab
; 30(1): 25-38, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30471920
ABSTRACT
Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based on their ER expression. Crosstalk between estrogen signaling elements and several key metabolic regulators alters metabolism in breast cancer cells, and enables tumors to rewire their metabolism to adapt to poor perfusion, transient nutrient deprivation, and increased acidity. This leads to the selection of drug-resistant and metastatic clones. In this review we discuss studies revealing the role of estrogen signaling elements in drug resistance development and metabolic adaptation during breast cancer progression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Transducción de Señal
/
Receptores de Estrógenos
/
Estrógenos
/
Redes y Vías Metabólicas
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2019
Tipo del documento:
Article