Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

Bamidele, Adebowale O; Svingen, Phyllis A; Sagstetter, Mary R; Sarmento, Olga F; Gonzalez, Michelle; Braga Neto, Manuel B; Kugathasan, Subra; Lomberk, Gwen; Urrutia, Raul A; Faubion, William A

Bamidele, Adebowale O; Svingen, Phyllis A; Sagstetter, Mary R; Sarmento, Olga F; Gonzalez, Michelle; Braga Neto, Manuel B; Kugathasan, Subra; Lomberk, Gwen; Urrutia, Raul A; Faubion, William A.

Afiliación

Bamidele AO; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Svingen PA; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Sagstetter MR; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Sarmento OF; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Gonzalez M; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Braga Neto MB; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Kugathasan S; Department of Pediatrics, Emory University, School of Medicine, Atlanta, Georgia.
Lomberk G; Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Urrutia RA; Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Faubion WA; Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: Faubion.William@mayo.edu.

Cell Mol Gastroenterol Hepatol ; 7(1): 55-71, 2019.

Article en En | MEDLINE | ID: mdl-30510991

Asunto(s)

Proteína Potenciadora del Homólogo Zeste 2/metabolismo; Factores de Transcripción Forkhead/metabolismo; Inflamación/metabolismo; Inflamación/patología; Intestinos/patología; Adulto; Animales; Núcleo Celular/metabolismo; Separación Celular; Proteínas Co-Represoras/metabolismo; Femenino; Humanos; Inflamación/inmunología; Enfermedades Inflamatorias del Intestino/inmunología; Enfermedades Inflamatorias del Intestino/patología; Interleucina-6/metabolismo; Quinasas Janus/metabolismo; Células Jurkat; Masculino; Ratones Endogámicos C57BL; Persona de Mediana Edad; Mutación/genética; Fosforilación; Fosfotirosina/metabolismo; Complejo Represivo Polycomb 2/metabolismo; Unión Proteica; Factor de Transcripción STAT3/metabolismo; Transducción de Señal; Linfocitos T Reguladores/metabolismo

Palabras clave

C232, cysteine 232; CD, Crohn's disease; ChIP, chromatin-immunoprecipitation; Crohn's Disease; EED, embryonic ectoderm development; EZH2, enhancer of zeste homolog 2; Epigenetics; FCS, fetal calf serum; FOXP3, forkhead domain-containing X-chromosomeencoded protein; H3K27me3, trimethylated histone H3 at lysine 27; IBD, inflammatory bowel disease; IL, interleukin; IPEX, immune dysregulation, polyendocrinopathy, enteropathy, X-linked; JAK, Janus kinase; LZ, leucine zipper; PBMC, peripheral blood mononuclear cell; PBS, phosphate-buffered saline; PLA, proximity ligation assay; PMA, phorbol 12-myristate 13-acetate; PRC2, polycomb repressive complex 2; Proinflammatory Cytokine; Regulatory T Cells; STAT, signal transducer and activator of transcription; SUZ12, suppressor of zeste; Th, T helper; Treg, regulatory T cell; WT, wild-type; co-IP, co-immunoprecipitation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción Forkhead / Proteína Potenciadora del Homólogo Zeste 2 / Inflamación / Intestinos Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Mol Gastroenterol Hepatol Año: 2019 Tipo del documento: Article

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