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A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
Campagna, Jesus; Spilman, Patricia; Jagodzinska, Barbara; Bai, Dongsheng; Hatami, Asa; Zhu, Chunni; Bilousova, Tina; Jun, Michael; Elias, Chris Jean; Pham, Johnny; Cole, Gregory; LaDu, Mary Jo; Jung, Michael E; Bredesen, Dale E; John, Varghese.
Afiliación
  • Campagna J; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Spilman P; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Jagodzinska B; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Bai D; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Hatami A; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Zhu C; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Bilousova T; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Jun M; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Elias CJ; The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • Pham J; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
  • Cole G; Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
  • LaDu MJ; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
  • Jung ME; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, 60612, USA.
  • Bredesen DE; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
  • John V; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Sci Rep ; 8(1): 17574, 2018 12 04.
Article en En | MEDLINE | ID: mdl-30514854
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Selectivos de la Recaptación de Serotonina / Apolipoproteína E4 / Sirtuina 1 / Sirtuina 2 / Enfermedad de Alzheimer / Hipocampo / Antiparkinsonianos Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Selectivos de la Recaptación de Serotonina / Apolipoproteína E4 / Sirtuina 1 / Sirtuina 2 / Enfermedad de Alzheimer / Hipocampo / Antiparkinsonianos Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos