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Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.
Wang, Lu; Zhang, Yanmin; Zhang, Qing; Zhu, Gaoyuan; Zhang, Zhimin; Duan, Chunqi; Lu, Tao; Tang, Weifang.
Afiliación
  • Wang L; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
  • Zhang Y; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
  • Zhang Q; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
  • Zhu G; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
  • Zhang Z; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
  • Duan C; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
  • Lu T; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu 210009, China. Electronic address: lutao@cpu.edu.cn.
  • Tang W; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: twf@cpu.edu.cn.
Eur J Med Chem ; 163: 243-255, 2019 Feb 01.
Article en En | MEDLINE | ID: mdl-30529543
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: China