PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data.

Cooper, Alexander B; Aggarwal, Manoj; Bartels, Michael J; Morriss, Alistair; Terry, Claire; Lord, Gwyn A; Gant, Timothy W

Cooper, Alexander B; Aggarwal, Manoj; Bartels, Michael J; Morriss, Alistair; Terry, Claire; Lord, Gwyn A; Gant, Timothy W.

Afiliación

Cooper AB; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Campus, Didcot, OX11 0RQ, UK. Electronic address: Alexander.Cooper@food.gov.uk.
Aggarwal M; Dow AgroSciences, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK.
Bartels MJ; Dow AgroSciences, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK.
Morriss A; Dow AgroSciences, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK.
Terry C; Dow AgroSciences, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK.
Lord GA; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Campus, Didcot, OX11 0RQ, UK.
Gant TW; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Campus, Didcot, OX11 0RQ, UK; Kings College London, Department of Analytical, Environmental & Forensic Sciences, James Clerk Maxwell Building 57 Waterloo Road, London, SE1 8WA, UK. Electronic address: Tim.Ga

Regul Toxicol Pharmacol ; 102: 1-12, 2019 Mar.

Article en En | MEDLINE | ID: mdl-30543831

Asunto(s)

Herbicidas/farmacocinética; Herbicidas/toxicidad; Hígado/metabolismo; Modelos Biológicos; Modelos Estadísticos; Exposición Profesional/análisis; Piridinas/farmacocinética; Piridinas/toxicidad; Adulto; Anciano; Animales; Teorema de Bayes; Monitoreo del Ambiente; Agricultores; Humanos; Masculino; Cadenas de Markov; Ratones; Persona de Mediana Edad; Método de Montecarlo; Nivel sin Efectos Adversos Observados; Exposición Profesional/efectos adversos; Medición de Riesgo; Toxicocinética; Adulto Joven

Palabras clave

Bayesian analysis; Haloxyfop; PBTK model; Pesticides; Risk assessment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 12_ODS3_hazardous_contamination / 2_ODS3 Problema de salud: 12_occupational_exposures / 2_quimicos_contaminacion Asunto principal: Piridinas / Modelos Estadísticos / Exposición Profesional / Herbicidas / Hígado / Modelos Biológicos Tipo de estudio: Etiology_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: Regul Toxicol Pharmacol Año: 2019 Tipo del documento: Article

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