Secondary skin involvement in gastric diffuse large B-cell lymphoma treated with chidamide: A case report.
Medicine (Baltimore)
; 97(49): e13093, 2018 Dec.
Article
en En
| MEDLINE
| ID: mdl-30544372
ABSTRACT
RATIONALE Diffuse large B-cell lymphoma (DLBCL) is a neoplasm of large B lymphoid cells that exhibits diffuse growth patterns. Patients may present with nodal and/or extranodal disease. The most common extranodal site is the gastrointestinal tract, while skin is less common. PATIENT CONCERNS We report a case of secondary skin involvement of an original gastric DLBCL, which has achieved a complete response after treatment with chidamide. DIAGNOSES Initially, the diagnosis of gastric DLBCL is clear, and this patient responded well to systemic chemotherapy (rituximab + cyclophosphamide + epirubicin + vincristine + prednisone) after 8 cycles. Thirty months later, some rapidly enlarging skin nodules on his arm were found. These skin nodules were diagnosed as secondary cutaneous DLBCL based on the clinical features, positron emission tomography-computed tomography, and histomorphologic and immunohistochemical expression. INTERVENTIONS:
Steroids, interferon-α, and radiation had little therapeutic effect. We treated the patient with chidamide at 30âmg twice per week in combination with dexamethasone.OUTCOMES:
The skin nodules regressed 3 weeks later. During the 1-year follow-up period, the patient is still in treatment with chidamide without adverse reactions. LESSONS To the best of our knowledge, this is the first case of secondary skin DLBCL reported to exhibit a complete response to chidamide, which provides a novel therapeutic strategy for secondary skin DLBCL. However, more cases are still needed to further validate its efficacy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Neoplasias Gástricas
/
Benzamidas
/
Linfoma no Hodgkin
/
Linfoma de Células B Grandes Difuso
/
Aminopiridinas
/
Antineoplásicos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2018
Tipo del documento:
Article