Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane.
iScience
; 10: 234-244, 2018 Dec 21.
Article
en En
| MEDLINE
| ID: mdl-30557785
ABSTRACT
Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
IScience
Año:
2018
Tipo del documento:
Article
País de afiliación:
Reino Unido