MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer.
Biomed Pharmacother
; 110: 850-856, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-30557834
ABSTRACT
MicroRNA-542-3p (miR-542-3p) has been implicated in several cancers; however, its precise role in ovarian cancer is unclear. In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. An in vivo assay also revealed that miR-542-3p overexpression significantly attenuated tumor growth. Mechanistically, the gene of cyclin-dependent kinase 14 (CDK14) was identified as a novel target of miR-542-3p. CDK14 overexpression reversed the suppressive effects of miR-542-3p in ovarian cancer cells. Collectively, these results suggest that miR-542-3p functions as a tumor-suppressive miRNA in ovarian cancer by directly targeting CDK14. Our data provide novel insights into potential future treatments for patients with ovarian cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Quinasas Ciclina-Dependientes
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MicroARNs
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Proliferación Celular
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Carcinogénesis
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Carcinoma Epitelial de Ovario
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Biomed Pharmacother
Año:
2019
Tipo del documento:
Article
País de afiliación:
China