Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies.
Bioorg Chem
; 85: 109-116, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30605884
ABSTRACT
New series of quinoline-based thiadiazole analogs (1-20) were synthesized, characterized by EI-MS, 1H NMR and 13C NMR. All synthesized compounds were subjected to their antileishmanial potential. Sixteen analogs 1-10, 12, 13, 16, 17, 18 and 19 with IC50 values in the range of 0.04⯱â¯0.01 to 5.60⯱â¯0.21⯵M showed tremendously potent inhibition as compared to the standard pentamidine with IC50 value 7.02⯱â¯0.09⯵M. Analogs 11, 14, 15 and 20 with IC50 8.20⯱â¯0.35, 9.20⯱â¯0.40, 7.20⯱â¯0.20 and 9.60⯱â¯0.40⯵M respectively showed good inhibition when compared with the standard. Structure-activity relationships have been also established for all compounds. Molecular docking studies were performed to determine the binding interaction of the compounds with the active site target.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Tiadiazoles
/
Tripanocidas
Idioma:
En
Revista:
Bioorg Chem
Año:
2019
Tipo del documento:
Article
País de afiliación:
Arabia Saudita