Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor.
J Asian Nat Prod Res
; 21(8): 754-771, 2019 Aug.
Article
en En
| MEDLINE
| ID: mdl-30606060
ABSTRACT
Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that the uptake ratio of andrographolide was less than 2.0 at all concentrations tested, indicating that andrographolide is not a hOAT1 substrate. Andrographolide has no significant effects on the p-aminohippuric acid uptake and on the mRNA and protein expression of hOAT1. In conclusion, andrographolide may not pose a drug-herb interaction risk related to hOAT1.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína 1 de Transporte de Anión Orgánico
/
Diterpenos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Malasia