A transgenerational toxicokinetic model and its use in derivation of Minnesota PFOA water guidance.
J Expo Sci Environ Epidemiol
; 29(2): 183-195, 2019 03.
Article
en En
| MEDLINE
| ID: mdl-30631142
ABSTRACT
Minnesota has been grappling with extensive per- and polyfluoroalkyl substances (PFASs) groundwater contamination since 2002, in a major metropolitan setting. As toxicological information has accumulated for these substances, the public health community has become increasingly aware of critically sensitive populations. The accumulation of some PFAS in women of childbearing age, and the placental and breastmilk transfer to their offspring, require new risk assessment methods to protect public health. The traditional water guidance paradigm is inadequate to address maternal-to-infant transfer of accumulated levels of perfluorooctanoate (PFOA), in particular. Even short exposures during infancy have dramatic impacts on serum levels for many years. In addition, developmental effects are the critical effects anchoring recent risk assessments. In response, the Minnesota Department of Health created an Excel-based model that incorporates chemical-specific properties and exposure parameters for early life stages. Serum levels were assessed in both formula-fed and breastfed infants, with placental transfer in both scenarios. Peak breastfed infant serum levels were 4.4-fold higher than in formula-fed infants, with both of these scenarios producing serum levels in excess of the adult steady-state level. The development and application of this model to PFOA are described.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Contaminantes Químicos del Agua
/
Agua Potable
/
Caprilatos
/
Exposición a Riesgos Ambientales
/
Fluorocarburos
Tipo de estudio:
Guideline
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Infant
/
Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Expo Sci Environ Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
SAUDE AMBIENTAL
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos