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Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.
Norheim, Frode; Hasin-Brumshtein, Yehudit; Vergnes, Laurent; Chella Krishnan, Karthickeyan; Pan, Calvin; Seldin, Marcus M; Hui, Simon T; Mehrabian, Margarete; Zhou, Zhiqiang; Gupta, Sonul; Parks, Brian W; Walch, Axel; Reue, Karen; Hofmann, Susanna M; Arnold, Arthur P; Lusis, Aldons J.
Afiliación
  • Norheim F; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Hasin-Brumshtein Y; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Vergnes L; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Chella Krishnan K; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Pan C; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Seldin MM; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Hui ST; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Mehrabian M; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Zhou Z; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Gupta S; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Parks BW; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
  • Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany.
  • Reue K; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Hofmann SM; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, München 80336, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximili
  • Arnold AP; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Lusis AJ; Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, Unive
Cell Metab ; 29(4): 932-949.e4, 2019 04 02.
Article en En | MEDLINE | ID: mdl-30639359
ABSTRACT
We studied sex differences in over 50 cardio-metabolic traits in a panel of 100 diverse inbred strains of mice. The results clearly showed that the effects of sex on both clinical phenotypes and gene expression depend on the genetic background. In support of this, genetic loci associated with the traits frequently showed sex specificity. For example, Lyplal1, a gene implicated in human obesity, was shown to underlie a sex-specific locus for diet-induced obesity. Global gene expression analyses of tissues across the panel implicated adipose tissue "beiging" and mitochondrial functions in the sex differences. Isolated mitochondria showed gene-by-sex interactions in oxidative functions, such that some strains (C57BL/6J) showed similar function between sexes, whereas others (DBA/2J and A/J) showed increased function in females. Reduced adipose mitochondrial function in males as compared to females was associated with increased susceptibility to obesity and insulin resistance. Gonadectomy studies indicated that gonadal hormones acting in a tissue-specific manner were responsible in part for the sex differences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Mitocondrias Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Noruega
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Mitocondrias Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Noruega