p16 Influence on Laryngeal Squamous Cell Carcinoma Relapse and Survival.
Otolaryngol Head Neck Surg
; 160(6): 1042-1047, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30642220
ABSTRACT
OBJECTIVE:
(1) To identify p16 protein in laryngeal squamous cell carcinoma (LSCC) specimens and to correlate it with the presence of human papillomavirus (HPV) found in these specimens from a previous study. (2) To analyze p16 impact on 10-year overall and disease-free survival. STUDYDESIGN:
Retrospective case series with oncologic database chart review.SETTING:
Academic tertiary care hospital.SUBJECTS:
A total of 123 samples of LSCC (taken from the glottis only) from patients treated with primary surgical resection between 1977 and 2005.METHODS:
p16 protein expression was analyzed through immunohistochemistry and compared with the presence of HPV established in our previous studies. Results were compared with histologic, clinicopathologic, and survival parameters, with a 10-year follow-up.RESULTS:
Of the samples, 39.02% were positive for p16, but only 11.38% were positive for both p16 and HPV. The p16+ cohort showed a significant improvement in disease-free survival ( P = .0022); statistical significance was not achieved for overall survival. p16+ cases had fewer relapses over time, with no relapses after a 2-year follow-up. Age at the time of diagnosis and tobacco consumption were the only epidemiologic factors that influenced overall survival.CONCLUSION:
The expression of p16 protein was a beneficial prognostic factor for disease-free survival among patients with LSCC of the glottis, with no relapses after a 2-year follow-up.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Inhibidor p16 de la Quinasa Dependiente de Ciclina
/
Infecciones por Papillomavirus
/
Glotis
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
España