Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction.

Coblentz, Philip D; Ahn, Bumsoo; Hayward, Linda F; Yoo, Jeung-Ki; Christou, Demetra D; Ferreira, Leonardo F

Coblentz, Philip D; Ahn, Bumsoo; Hayward, Linda F; Yoo, Jeung-Ki; Christou, Demetra D; Ferreira, Leonardo F.

Afiliación

Coblentz PD; Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida , Gainesville, Florida.
Ahn B; Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida , Gainesville, Florida.
Hayward LF; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida , Gainesville, Florida.
Yoo JK; Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida , Gainesville, Florida.
Christou DD; Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida , Gainesville, Florida.
Ferreira LF; Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida , Gainesville, Florida.

Am J Physiol Lung Cell Mol Physiol ; 316(4): L679-L690, 2019 04 01.

Article en En | MEDLINE | ID: mdl-30702345

Asunto(s)

Diafragma/fisiopatología; Insuficiencia Cardíaca/fisiopatología; Debilidad Muscular/prevención & control; ARN Interferente Pequeño/genética; Esfingomielina Fosfodiesterasa/antagonistas & inhibidores; Esfingomielina Fosfodiesterasa/genética; Compuestos de Anilina/farmacología; Animales; Compuestos de Bencilideno/farmacología; Diafragma/enzimología; Modelos Animales de Enfermedad; Insuficiencia Cardíaca/genética; Insuficiencia Cardíaca/terapia; Humanos; Masculino; Ratones; Ratones Noqueados; Debilidad Muscular/genética; Debilidad Muscular/fisiopatología; Ratas; Ratas Wistar; Esfingomielina Fosfodiesterasa/deficiencia; Volumen Sistólico/genética; Volumen Sistólico/fisiología

Palabras clave

ceramide; mitochondria; myocardial infarction; oxidants; skeletal muscle; tachypnea

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Diafragma / Debilidad Muscular / ARN Interferente Pequeño / Insuficiencia Cardíaca Límite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2019 Tipo del documento: Article

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