Nanomedicine for Cystic Fibrosis.
SLAS Technol
; 24(2): 169-180, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30707858
ABSTRACT
Cystic fibrosis is a genetic disease affecting more than 70,000 people worldwide. Caused by a mutation in the CFTR gene, cystic fibrosis can result in difficulty breathing, widespread bacterial infections, edema, malnutrition, pancreatitis, and death. Current drug-based treatments struggle to reach the site of action due to the thick mucus, and only manage symptoms such as blocked airways, lung infections, and limited ability to digest food. Nanotechnology opens up possibilities for improved treatment strategies by focusing on drug penetration through the mucus lining, eliminating resulting bacterial infections, and targeting the underlying genetic cause of the disease. In this review, we present recent nanoparticle developments for cystic fibrosis, challenges in nanomedicine therapeutics, and future research directions in gene editing and nonviral vectors for gene delivery.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_endocrine_disorders
/
6_other_respiratory_diseases
Asunto principal:
Portadores de Fármacos
/
Terapia Genética
/
Sistemas de Liberación de Medicamentos
/
Fibrosis Quística
/
Nanomedicina
/
Nanopartículas
/
Terapia Molecular Dirigida
Límite:
Humans
Idioma:
En
Revista:
SLAS Technol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos