Chronic cardiovascular toxicity in the older oncology patient population.
J Geriatr Oncol
; 10(5): 685-689, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-30733001
ABSTRACT
Survivorship statistics demonstrate that the incidence of cancer continues to rise worldwide, with a further 60% increase in diagnoses predicted by 2030 attributed to lifestyle risk factors, screening programmes resulting in earlier diagnosis but also the changing demographics of the population. More than a third of new cancer diagnoses and almost half of cancer survivors are now aged 70â¯years or older. Despite this increasing incidence, worldwide five-year cancer survival rates have improved significantly over the past two decades. After cancer, cardiovascular disease is the second most common cause of death in developed countries. With continued improvements in overall prognosis, patients with cancer have an increased exposure to cardiovascular risk factors resulting in higher cardiovascular morbidity and mortality, particularly in older patients. This relationship between cancer and cardiovascular disease is not surprising as they share the common risk factors of aging, smoking, obesity, and poor diet. In this review, we discuss the toxicity of cancer treatments on the cardiovascular system, particularly in older patients. We focus primarily on radiotherapy and anthracycline chemotherapy because of their chronic adverse effects and appraise approaches toward the detection and treatment of this toxicity to maximise survival and quality of life of older patients with cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
1_doencas_nao_transmissiveis
/
2_muertes_prematuras_enfermedades_notrasmisibles
/
6_breast_cancer
/
6_cardiovascular_diseases
/
6_ischemic_heart_disease
/
6_other_circulatory_diseases
Asunto principal:
Traumatismos por Radiación
/
Enfermedades Cardiovasculares
/
Disfunción Ventricular Izquierda
/
Antraciclinas
/
Estenosis Coronaria
/
Insuficiencia Cardíaca
/
Cardiomiopatías
/
Neoplasias
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Aspecto:
Patient_preference
Límite:
Aged
/
Humans
Idioma:
En
Revista:
J Geriatr Oncol
Año:
2019
Tipo del documento:
Article