[Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)]. / Syndrome de Lyell d'évolution fatale suite à la réadministration de diclofénac, au CHU de Bouaké (Côte d'Ivoire).

ABSTRACT

Lyell's syndrome or toxic epidermal necrolysis is an acute and severe cutaneous adverse drug reaction with a significant morbidity and mortality. It is a very rare condition but a vital emergency with a poor prognosis. The diagnosis is clinical and confirmed by a cutaneous biopsy showing a necrosis of the epidermis. It can be due to many drugs including non-steroidal anti-inflammatory drugs. We report a case of fatal Lyell's syndrome after oral re-administration of diclofenac in a patient with a previous history of diclofenac-related Stevens-Johnson syndrome, four years back.

Nous rapportons un cas de syndrome de Lyell mortel après réadministration orale de diclofénac chez un patient ayant des antécédents de syndrome de Stevens-Johnson lié au diclofénac quatre ans auparavant.