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Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.
Silva, Tiago; Mohamed, Tarek; Shakeri, Arash; Rao, Praveen P N; Soares da Silva, Patrício; Remião, Fernando; Borges, Fernanda.
Afiliación
  • Silva T; CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
  • Mohamed T; School of Pharmacy, Health Sciences Campus, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada.
  • Shakeri A; School of Pharmacy, Health Sciences Campus, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada.
  • Rao PPN; School of Pharmacy, Health Sciences Campus, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada. Electronic address: praoperampallinekkar@uwaterloo.ca.
  • Soares da Silva P; Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, 4200-319, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
  • Remião F; UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
  • Borges F; CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal. Electronic address: fborges@fc.up.pt.
Eur J Med Chem ; 167: 146-152, 2019 Apr 01.
Article en En | MEDLINE | ID: mdl-30771602
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Ácidos Cafeicos / Catecoles / Agregación Patológica de Proteínas / Nitrocompuestos Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Portugal
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Ácidos Cafeicos / Catecoles / Agregación Patológica de Proteínas / Nitrocompuestos Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Portugal