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Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.
Ortiz-Álvarez, Gonzalo; Daclin, Marie; Shihavuddin, Asm; Lansade, Pauline; Fortoul, Aurélien; Faucourt, Marion; Clavreul, Solène; Lalioti, Maria-Eleni; Taraviras, Stavros; Hippenmeyer, Simon; Livet, Jean; Meunier, Alice; Genovesio, Auguste; Spassky, Nathalie.
Afiliación
  • Ortiz-Álvarez G; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Daclin M; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Shihavuddin A; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Lansade P; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Fortoul A; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Faucourt M; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Clavreul S; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France.
  • Lalioti ME; Department of Physiology, Medical School, University of Patras, 26504 Rio, Patras, Greece.
  • Taraviras S; Department of Physiology, Medical School, University of Patras, 26504 Rio, Patras, Greece.
  • Hippenmeyer S; Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
  • Livet J; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France.
  • Meunier A; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Genovesio A; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France.
  • Spassky N; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France. Electronic address: nathalie.spassky@ens.fr.
Neuron ; 102(1): 159-172.e7, 2019 04 03.
Article en En | MEDLINE | ID: mdl-30824354
Adult neural stem cells and multiciliated ependymal cells are glial cells essential for neurological functions. Together, they make up the adult neurogenic niche. Using both high-throughput clonal analysis and single-cell resolution of progenitor division patterns and fate, we show that these two components of the neurogenic niche are lineally related: adult neural stem cells are sister cells to ependymal cells, whereas most ependymal cells arise from the terminal symmetric divisions of the lineage. Unexpectedly, we found that the antagonist regulators of DNA replication, GemC1 and Geminin, can tune the proportion of neural stem cells and ependymal cells. Our findings reveal the controlled dynamic of the neurogenic niche ontogeny and identify the Geminin family members as key regulators of the initial pool of adult neural stem cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitos / Epéndimo / Células-Madre Neurales / Células Ependimogliales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitos / Epéndimo / Células-Madre Neurales / Células Ependimogliales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Francia
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