p53 ß-hydroxybutyrylation attenuates p53 activity.

Liu, Kun; Li, Fangzhou; Sun, Qianqian; Lin, Ning; Han, Haichao; You, Kaiqiang; Tian, Feng; Mao, Zebin; Li, Tingting; Tong, Tanjun; Geng, Meiyu; Zhao, Yingming; Gu, Wei; Zhao, Wenhui

Liu, Kun; Li, Fangzhou; Sun, Qianqian; Lin, Ning; Han, Haichao; You, Kaiqiang; Tian, Feng; Mao, Zebin; Li, Tingting; Tong, Tanjun; Geng, Meiyu; Zhao, Yingming; Gu, Wei; Zhao, Wenhui.

Afiliación

Liu K; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Li F; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Sun Q; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Lin N; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Han H; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
You K; Department of Biomedical Informatics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Tian F; Department of Laboratory Animal Science, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Mao Z; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Li T; Department of Biomedical Informatics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Tong T; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Geng M; Department of Pharmacology I, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, 201203, Pudong, Shanghai, China.
Zhao Y; Ben May Department of Cancer Research, The University of Chicago, Chicago, IL, USA.
Gu W; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY, 10032, USA.
Zhao W; Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China. zhao6025729@bjmu.edu.cn.

Cell Death Dis ; 10(3): 243, 2019 03 11.

Article en En | MEDLINE | ID: mdl-30858356

Asunto(s)

Ácido 3-Hidroxibutírico/metabolismo; Apoptosis/efectos de los fármacos; Lisina/metabolismo; Proteína p53 Supresora de Tumor/química; Proteína p53 Supresora de Tumor/metabolismo; Ácido 3-Hidroxibutírico/sangre; Ácido 3-Hidroxibutírico/farmacología; Acetilación; Animales; Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Cromatografía Liquida; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/genética; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Daño del ADN/efectos de los fármacos; Daño del ADN/genética; Células HEK293; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; Fragmentos de Péptidos/genética; Fragmentos de Péptidos/metabolismo; Procesamiento Proteico-Postraduccional; Sialoglicoproteínas/genética; Sialoglicoproteínas/metabolismo; Espectrometría de Masas en Tándem; Timo/metabolismo; Timo/efectos de la radiación; Proteína p53 Supresora de Tumor/antagonistas & inhibidores; Proteína p53 Supresora de Tumor/genética; Proteínas Supresoras de Tumor/genética; Proteínas Supresoras de Tumor/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Apoptosis / Ácido 3-Hidroxibutírico / Lisina Límite: Animals / Humans / Male Idioma: En Revista: Cell Death Dis Año: 2019 Tipo del documento: Article País de afiliación: China

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