Access to Unprotected ß-Fluoroalkyl ß-Amino Acids and Their α-Hydroxy Derivatives.
Org Lett
; 21(7): 2340-2345, 2019 04 05.
Article
en En
| MEDLINE
| ID: mdl-30873840
ABSTRACT
Unprotected ß-(het)aryl-ß-fluoroalkyl ß-amino acids and their α-hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated ß-amino acids as useful building blocks in a practical and scalable manner.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia