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Meningococcal Serogroup A, B, C, W, X, and Y Serum Bactericidal Antibody Assays.
Lucidarme, Jay; Louth, Jennifer; Townsend-Payne, Kelly; Borrow, Ray.
Afiliación
  • Lucidarme J; Meningococcal Reference Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.
  • Louth J; Vaccine Evaluation Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.
  • Townsend-Payne K; Vaccine Evaluation Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.
  • Borrow R; Meningococcal Reference Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK. ray.borrow@phe.gov.uk.
Methods Mol Biol ; 1969: 169-179, 2019.
Article en En | MEDLINE | ID: mdl-30877677
ABSTRACT
Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND / 4_TD Problema de salud: 2_enfermedades_transmissibles / 3_zoonosis / 4_meningitis Asunto principal: Proteínas del Sistema Complemento / Determinación de Anticuerpos Séricos Bactericidas / Serogrupo / Infecciones Meningocócicas / Anticuerpos Antibacterianos / Neisseria meningitidis Límite: Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND / 4_TD Problema de salud: 2_enfermedades_transmissibles / 3_zoonosis / 4_meningitis Asunto principal: Proteínas del Sistema Complemento / Determinación de Anticuerpos Séricos Bactericidas / Serogrupo / Infecciones Meningocócicas / Anticuerpos Antibacterianos / Neisseria meningitidis Límite: Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido