Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.

Bogie, Jeroen; Hoeks, Cindy; Schepers, Melissa; Tiane, Assia; Cuypers, Ann; Leijten, Frank; Chintapakorn, Yupyn; Suttiyut, Thiti; Pornpakakul, Surachai; Struik, Dicky; Kerksiek, Anja; Liu, Hong-Bing; Hellings, Niels; Martinez-Martinez, Pilar; Jonker, Johan W; Dewachter, Ilse; Sijbrands, Eric; Walter, Jochen; Hendriks, Jerome; Groen, Albert; Staels, Bart; Lütjohann, Dieter; Vanmierlo, Tim; Mulder, Monique

Bogie, Jeroen; Hoeks, Cindy; Schepers, Melissa; Tiane, Assia; Cuypers, Ann; Leijten, Frank; Chintapakorn, Yupyn; Suttiyut, Thiti; Pornpakakul, Surachai; Struik, Dicky; Kerksiek, Anja; Liu, Hong-Bing; Hellings, Niels; Martinez-Martinez, Pilar; Jonker, Johan W; Dewachter, Ilse; Sijbrands, Eric; Walter, Jochen; Hendriks, Jerome; Groen, Albert; Staels, Bart; Lütjohann, Dieter; Vanmierlo, Tim; Mulder, Monique.

Afiliación

Bogie J; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Hoeks C; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Schepers M; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Tiane A; School for mental health and neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Cuypers A; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Leijten F; School for mental health and neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Chintapakorn Y; Centre for Environmental Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Suttiyut T; Department of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Pornpakakul S; Center of Excellence in Environment and Plant Physiology, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Struik D; Center of Excellence in Environment and Plant Physiology, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Kerksiek A; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Liu HB; Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Hellings N; Institute for Clinical Chemistry and Clinical Pharmacology, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany.
Martinez-Martinez P; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road 5, 266003, Qingdao, China.
Jonker JW; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Dewachter I; School for mental health and neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Sijbrands E; Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Walter J; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Hendriks J; Department of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Groen A; Department of Neurology, Molecular Cell Biology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
Staels B; Department of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Lütjohann D; Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Vanmierlo T; University of Lille - EGID, Inserm, U1011, University Hospital CHU, Institut Pasteur de Lille, F-59019, Lille, France.
Mulder M; Institute for Clinical Chemistry and Clinical Pharmacology, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany.

Sci Rep ; 9(1): 4908, 2019 03 20.

Article en En | MEDLINE | ID: mdl-30894635

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Péptidos beta-Amiloides/genética; Receptores X del Hígado/genética; Fármacos Neuroprotectores/farmacología; Fragmentos de Péptidos/genética; Placa Amiloide/tratamiento farmacológico; Sargassum/química; Estigmasterol/análogos & derivados; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/fisiopatología; Péptidos beta-Amiloides/antagonistas & inhibidores; Péptidos beta-Amiloides/metabolismo; Compuestos de Anilina/farmacología; Animales; Astrocitos/citología; Astrocitos/efectos de los fármacos; Astrocitos/metabolismo; Cognición/efectos de los fármacos; Cognición/fisiología; Medios de Cultivo Condicionados/farmacología; Modelos Animales de Enfermedad; Regulación de la Expresión Génica; Genes Reporteros; Hipocampo/efectos de los fármacos; Hipocampo/metabolismo; Hipocampo/patología; Humanos; Receptores X del Hígado/agonistas; Receptores X del Hígado/metabolismo; Luciferasas/genética; Luciferasas/metabolismo; Masculino; Memoria a Corto Plazo/efectos de los fármacos; Memoria a Corto Plazo/fisiología; Ratones; Ratones Transgénicos; Microglía/citología; Microglía/efectos de los fármacos; Microglía/metabolismo; Fármacos Neuroprotectores/aislamiento & purificación; Fragmentos de Péptidos/antagonistas & inhibidores; Fragmentos de Péptidos/metabolismo; Placa Amiloide/genética; Placa Amiloide/metabolismo; Placa Amiloide/fisiopatología; Transducción de Señal; Estigmasterol/aislamiento & purificación; Estigmasterol/farmacología; Tiazoles/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Estigmasterol / Péptidos beta-Amiloides / Fármacos Neuroprotectores / Placa Amiloide / Sargassum / Enfermedad de Alzheimer / Receptores X del Hígado Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Bélgica

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