Semi-synthesis and structural elucidation of brevicanines A-D, four new C19-diterpenoid alkaloids with rotameric phenomenon from Aconitum brevicalcaratum.
Fitoterapia
; 134: 404-410, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30898729
ABSTRACT
Four new C19-diterpenoid alkaloids brevicanines A-D (1-4) with rotameric phenomenon were isolated from Aconitum brevicalcaratum. They all possessed an unusual axial chiral phenyl-quinazoline side chain and their structures were elucidated by extensive spectroscopic analysis and chemical methods. Meanwhile, brevicanines A and B were semi-synthesized from their parent compound scaconine to further confirm their structures. Variable-temperature NMR spectroscopy was also used to investigate the atropisomers of brevicanine A, in which two sets of signals in 1H NMR spectra were observed at room temperature and coalesced over 140⯰C. It's the first time to determine the atropisomeric preference of diterpenoid alkaloids.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aconitum
/
Diterpenos
/
Alcaloides
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2019
Tipo del documento:
Article