Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac.
J Pharm Sci
; 108(8): 2635-2642, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-30905700
ABSTRACT
This article shows how milling can be used to explore the phase diagram of pharmaceuticals. This process has been applied to sulindac. A short milling has been found to trigger a polymorphic transformation between form II and form I upon heating which is not seen in the nonmilled material. This possibility was clearly demonstrated to result from crystalline microstrains induced by the mechanical shocks. A long milling has been found to induce a total amorphization of the material. Moreover, the amorphous fraction produced during milling appears to have a complex recrystallization upon heating which depends on the milling time. The investigations have been mainly performed by differential scanning calorimetry and powder X-ray diffraction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulindac
/
Antiinflamatorios no Esteroideos
Idioma:
En
Revista:
J Pharm Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia