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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
He, Shuwen; Lai, Zhong; Hong, Qingmei; Shang, Jackie; Reibarkh, Mikhail; Kuethe, Jeffrey T; Liu, Jian; Guiadeen, Deodial; Krikorian, Arto D; Cernak, Timothy A; Dykstra, Kevin D; Sperbeck, Donald M; Wu, Zhicai; Yu, Yang; Yang, Ginger X; Jian, Tianying; Verras, Andreas; Sonatore, Lisa M; Wiltsie, Judyann; Chung, Christine C; Murphy, Beth A; Gorski, Judith N; Liu, Jinqi; Xiao, Jianying; Wolff, Michael; Tong, Sharon X; Madeira, Maria; Karanam, Bindhu V; Shen, Dong-Ming; Balkovec, James M; Pinto, Shirly; Nargund, Ravi P; DeVita, Robert J.
Afiliación
  • He S; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States. Electronic address: shuwen@kallyope.com.
  • Lai Z; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Hong Q; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Shang J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Reibarkh M; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Kuethe JT; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Liu J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Guiadeen D; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Krikorian AD; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Cernak TA; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Dykstra KD; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Sperbeck DM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Wu Z; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Yu Y; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Yang GX; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Jian T; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Verras A; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Sonatore LM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Wiltsie J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Chung CC; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Murphy BA; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Gorski JN; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Liu J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Xiao J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Wolff M; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Tong SX; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Madeira M; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Karanam BV; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Shen DM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Balkovec JM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Pinto S; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Nargund RP; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • DeVita RJ; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
Bioorg Med Chem Lett ; 29(10): 1182-1186, 2019 05 15.
Article en En | MEDLINE | ID: mdl-30926247
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bencimidazoles / Ácidos Carboxílicos / Inhibidores Enzimáticos / Diacilglicerol O-Acetiltransferasa Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bencimidazoles / Ácidos Carboxílicos / Inhibidores Enzimáticos / Diacilglicerol O-Acetiltransferasa Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article