Mechanistic insights into Nav1.7-dependent regulation of rat prostate cancer cell invasiveness revealed by toxin probes and proteomic analysis.

Chen, Bo; Zhang, Changxin; Wang, Zijun; Chen, Yan; Xie, Huali; Li, Sha; Liu, Xiaoqian; Liu, Zhonghua; Chen, Ping

Chen, Bo; Zhang, Changxin; Wang, Zijun; Chen, Yan; Xie, Huali; Li, Sha; Liu, Xiaoqian; Liu, Zhonghua; Chen, Ping.

Afiliación

Chen B; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Zhang C; The Key laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Wang Z; The Key laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Chen Y; The Key laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Xie H; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Li S; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Liu X; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Liu Z; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Chen P; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

FEBS J ; 286(13): 2549-2561, 2019 07.

Article en En | MEDLINE | ID: mdl-30927332

Asunto(s)

Movimiento Celular; Canal de Sodio Activado por Voltaje NAV1.7/metabolismo; Neoplasias de la Próstata/metabolismo; Proteoma/genética; Bloqueadores de los Canales de Sodio/farmacología; Tetrodotoxina/farmacología; Factores Despolimerizantes de la Actina/genética; Factores Despolimerizantes de la Actina/metabolismo; Animales; Anexina A2/genética; Anexina A2/metabolismo; Proteínas Portadoras/genética; Proteínas Portadoras/metabolismo; Línea Celular Tumoral; Masculino; Proteínas de Microfilamentos/genética; Proteínas de Microfilamentos/metabolismo; Canal de Sodio Activado por Voltaje NAV1.7/genética; Neoplasias de la Próstata/genética; Proteoma/metabolismo; Ratas; Transducción de Señal; Proteína de Unión al GTP rac1/genética; Proteína de Unión al GTP rac1/metabolismo; Proteínas de Unión al GTP rho/genética; Proteínas de Unión al GTP rho/metabolismo

Palabras clave

Nav1.7; invasiveness; prostate cancer; proteomics; toxin probes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Tetrodotoxina / Movimiento Celular / Proteoma / Bloqueadores de los Canales de Sodio / Canal de Sodio Activado por Voltaje NAV1.7 Límite: Animals Idioma: En Revista: FEBS J Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China

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