Tumor Heterogeneity as a Predictor of Response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer.

Greenbaum, Alissa; Martin, David R; Bocklage, Thèrése; Lee, Ji-Hyun; Ness, Scott A; Rajput, Ashwani

Greenbaum, Alissa; Martin, David R; Bocklage, Thèrése; Lee, Ji-Hyun; Ness, Scott A; Rajput, Ashwani.

Afiliación

Greenbaum A; Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM.
Martin DR; Department of Pathology, University of New Mexico, Albuquerque, NM.
Bocklage T; Department of Pathology and Laboratory Medicine, University of Kentucky Albert B. Chandler Hospital, Lexington, KY.
Lee JH; Department of Biostatistics, College of Public Health and Health Professions College of Medicine, University of Florida, Gainesville, FL.
Ness SA; Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM.
Rajput A; Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM. Electronic address: arajput@salud.unm.edu.

Clin Colorectal Cancer ; 18(2): 102-109, 2019 06.

Article en En | MEDLINE | ID: mdl-30935775

Asunto(s)

Adenocarcinoma/terapia; Biomarcadores de Tumor/genética; Quimioradioterapia Adyuvante/métodos; Terapia Neoadyuvante/métodos; Neoplasias del Recto/terapia; Adenocarcinoma/genética; Adenocarcinoma/mortalidad; Alelos; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Biopsia; Análisis Mutacional de ADN; Femenino; Heterogeneidad Genética; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Masculino; Mutación; Estadificación de Neoplasias; Selección de Paciente; Proctectomía; Pronóstico; Estudios Prospectivos; Neoplasias del Recto/genética; Neoplasias del Recto/mortalidad; Recto/patología; Recto/cirugía; Análisis de Supervivencia; Resultado del Tratamiento

Palabras clave

Bioinformatics; Colorectal cancer; Personalized medicine; Targeted sequencing; Translational research

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Adenocarcinoma / Biomarcadores de Tumor / Terapia Neoadyuvante / Quimioradioterapia Adyuvante Tipo de estudio: Observational_studies / Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Colorectal Cancer Asunto de la revista: GASTROENTEROLOGIA / NEOPLASIAS Año: 2019 Tipo del documento: Article

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