Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review).
Mol Med Rep
; 19(6): 4529-4535, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-30942405
ABSTRACT
The phosphatidylinositol 3kinase (PI3K)/protein kinase B (AKT) signaling pathway is involved in the regulation of multiple cellular physiological processes by activating downstream corresponding effector molecules, which serve an important role in the cell cycle, growth and proliferation. This is a common phenomenon; overactivation of the pathway is present in human malignancies and has been implicated in cancer progression, hence one of the important approaches to the treatment of tumors is rational drug design using molecular targets in the PI3K/AKT signaling pathway. In brief, the present review analyzed the effects of the PI3K/AKT signaling pathway on certain gynecological cancer types.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Fosfatidilinositol 3-Quinasas
/
Proteínas Proto-Oncogénicas c-akt
/
Neoplasias de los Genitales Femeninos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Mol Med Rep
Año:
2019
Tipo del documento:
Article