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In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus.
Esquivel, Rianne N; Patel, Ami; Kudchodkar, Sagar B; Park, Daniel H; Stettler, Karin; Beltramello, Martina; Allen, Jeffrey W; Mendoza, Janess; Ramos, Stephanie; Choi, Hyeree; Borole, Piyush; Asija, Kanika; Bah, Mamadou; Shaheen, Shareef; Chen, Jing; Yan, Jian; Durham, Amy C; Smith, Trevor R F; Broderick, Kate; Guibinga, Ghiabe; Muthumani, Kar; Corti, Davide; Humeau, Laurent; Weiner, David B.
Afiliación
  • Esquivel RN; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Patel A; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Kudchodkar SB; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Park DH; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Stettler K; Humabs BioMed: a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Beltramello M; Humabs BioMed: a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Allen JW; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Mendoza J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Ramos S; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Choi H; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Borole P; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Asija K; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Bah M; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Shaheen S; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Chen J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Yan J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Durham AC; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Broderick K; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Guibinga G; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Muthumani K; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA.
  • Corti D; Humabs BioMed: a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Humeau L; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Weiner DB; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA. Electronic address: dweiner@wistar.org.
Mol Ther ; 27(5): 974-985, 2019 05 08.
Article en En | MEDLINE | ID: mdl-30962164
ABSTRACT
Zika virus (ZIKV) infection is endemic to several world regions, and many others are at high risk for seasonal outbreaks. Synthetic DNA-encoded monoclonal antibody (DMAb) is an approach that enables in vivo delivery of highly potent mAbs to control infections. We engineered DMAb-ZK190, encoding the mAb ZK190 neutralizing antibody, which targets the ZIKV E protein DIII domain. In vivo-delivered DMAb-ZK190 achieved expression levels persisting >10 weeks in mice and >3 weeks in non-human primate (NHPs), which is protective against ZIKV infectious challenge. This study is the first demonstration of infectious disease control in NHPs following in vivo delivery of a nucleic acid-encoded antibody, supporting the importance of this new platform.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: ADN / Proteínas del Envoltorio Viral / Anticuerpos Neutralizantes / Infección por el Virus Zika Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: ADN / Proteínas del Envoltorio Viral / Anticuerpos Neutralizantes / Infección por el Virus Zika Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos