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Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC.
Li, Chenying; Dong, Lei; Su, Rui; Bi, Ying; Qing, Ying; Deng, Xiaolan; Zhou, Yile; Hu, Chao; Yu, Mengxia; Huang, Hao; Jiang, Xi; Li, Xia; He, Xiao; Zou, Dongling; Shen, Chao; Han, Li; Sun, Miao; Skibbe, Jennifer; Ferchen, Kyle; Qin, Xi; Weng, Hengyou; Huang, Huilin; Song, Chunxiao; Chen, Jianjun; Jin, Jie.
Afiliación
  • Li C; Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China;Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, China.
  • Dong L; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Su R; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • Bi Y; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Qing Y; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • Deng X; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Zhou Y; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • Hu C; Ludwig Institute for Cancer Research & Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Yu M; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Huang H; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • Jiang X; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Li X; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • He X; School of Pharmacy, China Medical University, Shenyang, Liaoning, China.
  • Zou D; Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China;Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, China.
  • Shen C; Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China;Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, China.
  • Han L; Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China;Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, China.
  • Sun M; Division of Gynecologic Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Skibbe J; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Ferchen K; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • Qin X; Department of Pharmacology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine;Institute of Hematology, Zhejiang University & Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, Zhejiang, China.
  • Weng H; Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China;Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, China.
  • Huang H; Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China;Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, China.
  • Song C; Department of Systems Biology & the Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, CA, USA.
  • Chen J; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
  • Jin J; Department of Gynecologic Oncology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.
Haematologica ; 105(1): 148-160, 2020 01.
Article en En | MEDLINE | ID: mdl-30975912

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Epigenoma Límite: Animals Idioma: En Revista: Haematologica Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Epigenoma Límite: Animals Idioma: En Revista: Haematologica Año: 2020 Tipo del documento: Article País de afiliación: China
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