Folding the genome into mitotic chromosomes.
Curr Opin Cell Biol
; 60: 19-26, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-30999230
ABSTRACT
How linear DNA molecules are packaged into compact cylindrical chromosomes in preparation for cell division has remained one of the central outstanding questions in cell biology. Condensin is a highly conserved protein complex that universally determines large-scale DNA geometry during mitotic chromosome assembly. A wide range of recently developed approaches, including super resolution microscopy, single molecule imaging, Hi-C analyses and computational modeling, have profoundly changed how we view mitotic chromosomes. This review highlights recent discoveries on chromosome architecture and condensin function.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosomas
/
Genoma
/
Mitosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Japón