Transarterial chemoembolization versus best supportive care for patients with hepatocellular carcinoma with portal vein tumor thrombusï¼a multicenter study.
Eur J Surg Oncol
; 45(8): 1460-1467, 2019 Aug.
Article
en En
| MEDLINE
| ID: mdl-31005471
ABSTRACT
BACKGROUND:
This study aims to compare the efficacy and safety of treatment after transarterial chemoembolization(TACE) with best supportive care (BSC) in patients with hepatocellular carcinoma (HCC) with PVTT.METHODS:
This retrospective study was conducted on 1,040 patients with HCC with PVTT who were treated either with TACE (nâ¯=â¯675) or BSC (nâ¯=â¯365). BSC did not include sorafenib. The two groups of patients were compared with or without propensity score matching. A subgroup analysis was subsequently performed by stratifying patients according to the stages of PVTT in the Cheng's PVTT classification.RESULTS:
In PVTTtypes I-III, TACE was associated with significantly better overall survival (OS) thanBSC (Pâ¯<â¯0.05). Within each type of PVTT for patients who received TACE or BSC, OS was significantly worse in patients with type IVPVTT than in any of the other three types of PVTT (all Pâ¯<â¯0.05). TACE was associated with better long-termOS than BSC after propensity score matching or on stratification by the PVTT types.CONCLUSION:
TACE was associated with better OS than BSC in HCC patients with PVTT types I-III but not type IV. Patients with type IV PVTT showed the worst prognosis, regardless of whether TACE or BSC was used.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_digestive_diseases
/
6_liver_cancer
Asunto principal:
Vena Porta
/
Quimioembolización Terapéutica
/
Carcinoma Hepatocelular
/
Espera Vigilante
/
Neoplasias Hepáticas
/
Células Neoplásicas Circulantes
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Eur J Surg Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2019
Tipo del documento:
Article
País de afiliación:
China