Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA.

Cai, Ang; Bian, Ke; Chen, Fangyi; Tang, Qi; Carley, Rachel; Li, Deyu; Cho, Bongsup P

Cai, Ang; Bian, Ke; Chen, Fangyi; Tang, Qi; Carley, Rachel; Li, Deyu; Cho, Bongsup P.

Afiliación

Cai A; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. angcai@uri.edu.
Bian K; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. kebian@uri.edu.
Chen F; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. fangyi_chen@uri.edu.
Tang Q; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. qitang@my.uri.edu.
Carley R; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. rachel_carley@my.uri.edu.
Li D; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. deyuli@uri.edu.
Cho BP; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA. bcho@uri.edu.

Molecules ; 24(8)2019 Apr 20.

Article en En | MEDLINE | ID: mdl-31009995

Asunto(s)

Compuestos de Aminobifenilo/química; Carcinógenos/química; Replicación del ADN; ADN/química; ADN/genética; Conformación de Ácido Nucleico; Compuestos de Aminobifenilo/toxicidad; Secuencia de Bases; Carcinógenos/toxicidad; Replicación del ADN/efectos de los fármacos; Cinética; Conformación Molecular; Conformación de Ácido Nucleico/efectos de los fármacos; Oligonucleótidos/química; Oligonucleótidos/genética

Palabras clave

4-aminobiphenyl; Klenow fragment; bulky DNA lesion; conformational heterogeneity; steady state enzyme kinetics; surface plasmon resonance (SPR) binding kinetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Carcinógenos / Replicación del ADN / Compuestos de Aminobifenilo / Conformación de Ácido Nucleico Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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