Lymphocytes upregulate CD36 in adipose tissue and liver.
Adipocyte
; 8(1): 154-163, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31035848
ABSTRACT
CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5-40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
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Tejido Adiposo
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Linfocitos T CD8-positivos
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Antígenos CD36
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Hígado
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Adipocyte
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos