Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.

Tian, Xiao-Peng; Wang, Chen-Yuan; Jin, Xiao-Han; Li, Mei; Wang, Feng-Wei; Huang, Wei-Juan; Yun, Jing-Ping; Xu, Rui-Hua; Cai, Qing-Qing; Xie, Dan

Tian, Xiao-Peng; Wang, Chen-Yuan; Jin, Xiao-Han; Li, Mei; Wang, Feng-Wei; Huang, Wei-Juan; Yun, Jing-Ping; Xu, Rui-Hua; Cai, Qing-Qing; Xie, Dan.

Afiliación

Tian XP; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Wang CY; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Jin XH; Department of Reproductive Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Li M; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Wang FW; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Huang WJ; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Yun JP; Department of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.
Xu RH; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Cai QQ; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xie D; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

Theranostics ; 9(7): 1965-1979, 2019.

Article en En | MEDLINE | ID: mdl-31037150

Asunto(s)

Carcinoma Hepatocelular/genética; Proliferación Celular/genética; Exosomas/genética; Neoplasias Hepáticas/genética; MicroARNs/genética; Metástasis de la Neoplasia/genética; Microambiente Tumoral/genética; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Progresión de la Enfermedad; Supervivencia sin Enfermedad; Transición Epitelial-Mesenquimal/genética; Femenino; Regulación Neoplásica de la Expresión Génica/genética; Humanos; Neoplasias Hepáticas/patología; Masculino; Persona de Mediana Edad; Metástasis de la Neoplasia/patología; Recurrencia Local de Neoplasia/genética; Transducción de Señal/genética; Activación Transcripcional/genética; Regulación hacia Arriba/genética

Palabras clave

acidic microenvironment; early-stage hepatocellular carcinoma; epithelial- mesenchymal transition; miR-10b; miR-21

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / MicroARNs / Proliferación Celular / Exosomas / Microambiente Tumoral / Neoplasias Hepáticas / Metástasis de la Neoplasia Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Theranostics Año: 2019 Tipo del documento: Article País de afiliación: China

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