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IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells.
Rodrigues Alves, Ana Paula Nunes; Fernandes, Jaqueline Cristina; Fenerich, Bruna Alves; Coelho-Silva, Juan Luiz; Scheucher, Priscila Santos; Simões, Belinda Pinto; Rego, Eduardo Magalhães; Ridley, Anne J; Machado-Neto, João Agostinho; Traina, Fabiola.
Afiliación
  • Rodrigues Alves APN; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Fernandes JC; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Fenerich BA; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Coelho-Silva JL; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Scheucher PS; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Simões BP; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Rego EM; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Ridley AJ; Randall Centre for Cell and Molecular Biophysics, King's College London, London, United Kingdom; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
  • Machado-Neto JA; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil.
  • Traina F; Department of Internal Medicine, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil. Electronic address: ftraina@fmrp.usp.br.
Cancer Lett ; 456: 59-68, 2019 08 01.
Article en En | MEDLINE | ID: mdl-31042587
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_leukemia Asunto principal: Pirazinas / Pirogalol / Sulfonamidas / Receptor IGF Tipo 1 / Proteínas Quinasas Activadas por Mitógenos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteínas Sustrato del Receptor de Insulina / Fosfatidilinositol 3-Quinasa / Serina-Treonina Quinasas TOR / Imidazoles Límite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Cancer Lett Año: 2019 Tipo del documento: Article País de afiliación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_leukemia Asunto principal: Pirazinas / Pirogalol / Sulfonamidas / Receptor IGF Tipo 1 / Proteínas Quinasas Activadas por Mitógenos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteínas Sustrato del Receptor de Insulina / Fosfatidilinositol 3-Quinasa / Serina-Treonina Quinasas TOR / Imidazoles Límite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Cancer Lett Año: 2019 Tipo del documento: Article País de afiliación: Brasil