Phage therapy: Current status and perspectives.
Med Res Rev
; 40(1): 459-463, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31062882
ABSTRACT
The spread of antimicrobial resistant bacterial pathogens combined with the lack of new drug classes in the antibiotic pipeline causes a resurgence of the use of bacterial viruses (phages) to treat bacterial infections (phage therapy [PT]). There has been a substantial increase in patients subjected to this experimental therapy and emergence of new PT centers in Europe and the United States paralleled by one clinical trial completed in accord with good medical practice (GMP) requirements and a few others underway. What is more, evidence has been accumulating to suggest that phages can also exert anti-inflammatory and immunomodulatory action which opens new pathways for the development of novel targets for PT. Here we present the status quo of the PT, recent regulatory, and clinical developments as well as new perspectives for its wider application in clinical medicine.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terapia de Fagos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Med Res Rev
Año:
2020
Tipo del documento:
Article
País de afiliación:
Polonia