Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean.
J Helminthol
; 94: e53, 2019 May 16.
Article
en En
| MEDLINE
| ID: mdl-31092301
ABSTRACT
Neglected tropical diseases (NTDs) share certain traits they are parasitic infections, prevailing in tropical environments and affecting marginalized sectors of the population. Six NTDs - ascariasis, cysticercosis, echinococcosis, hookworm infection, onchocerciasis and trichuriasis - all of them endemic in Latin America and the Caribbean (LAC), are analysed in this work. This review aims to discuss key information on the function of excretory/secretory (E/S) proteins from these parasites in their infectivity, pathogeny and diagnosis. The modulation of the host immune system to favour the permanence and survival of the parasite is also discussed. An updated knowledge on the function of E/S molecules in endemic parasitoses in LAC may lead to new approaches for the clinical management and diagnosis of these diseases. In turn, this could allow us to optimize their treatment and make it more affordable - a relevant goal given the economic constraints that the region is facing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
Problema de salud:
2_enfermedades_transmissibles
/
3_helminthiasis
/
3_neglected_diseases
/
3_onchocerciasis
/
3_zoonosis
Asunto principal:
Proteínas del Helminto
/
Enfermedades Endémicas
/
Enfermedades Desatendidas
/
Helmintiasis
/
Sistema Inmunológico
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Helminthol
Año:
2019
Tipo del documento:
Article
País de afiliación:
México