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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.
Zhan, Tianzuo; Ambrosi, Giulia; Wandmacher, Anna Maxi; Rauscher, Benedikt; Betge, Johannes; Rindtorff, Niklas; Häussler, Ragna S; Hinsenkamp, Isabel; Bamberg, Leonhard; Hessling, Bernd; Müller-Decker, Karin; Erdmann, Gerrit; Burgermeister, Elke; Ebert, Matthias P; Boutros, Michael.
Afiliación
  • Zhan T; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.
  • Ambrosi G; Department of Internal Medicine II of the Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
  • Wandmacher AM; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.
  • Rauscher B; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.
  • Betge J; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.
  • Rindtorff N; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.
  • Häussler RS; Department of Internal Medicine II of the Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
  • Hinsenkamp I; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.
  • Bamberg L; NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.
  • Hessling B; Department of Internal Medicine II of the Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
  • Müller-Decker K; Department of Internal Medicine II of the Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
  • Erdmann G; Proteomics Core Facility, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Burgermeister E; Core Facility Tumor Models, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Ebert MP; NMI TT Pharmaservices, 13353, Berlin, Germany.
  • Boutros M; Department of Internal Medicine II of the Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
Nat Commun ; 10(1): 2197, 2019 05 16.
Article en En | MEDLINE | ID: mdl-31097693
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales / Quinasas de Proteína Quinasa Activadas por Mitógenos / Inhibidores de Proteínas Quinasas / Vía de Señalización Wnt / Antineoplásicos Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales / Quinasas de Proteína Quinasa Activadas por Mitógenos / Inhibidores de Proteínas Quinasas / Vía de Señalización Wnt / Antineoplásicos Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania