Knockdown of KIAA1199 suppresses IL-1ß-induced cartilage degradation and inflammatory responses in human chondrocytes through the Wnt/ß-catenin signalling pathway.

Ding, Qian-Hai; Qi, Yi-Ying; Li, Xiu-Mao; Chen, Wei-Ping; Wang, Xiang-Hua; Ji, Xiao-Wei

Ding, Qian-Hai; Qi, Yi-Ying; Li, Xiu-Mao; Chen, Wei-Ping; Wang, Xiang-Hua; Ji, Xiao-Wei.

Afiliación

Ding QH; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Qi YY; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Li XM; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Chen WP; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Wang XH; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Ji XW; Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China. Electronic address: xwji2013@zju.edu.cn.

Int Immunopharmacol ; 73: 203-211, 2019 Aug.

Article en En | MEDLINE | ID: mdl-31103876

Asunto(s)

Cartílago Articular/metabolismo; Condrocitos/metabolismo; Hialuronoglucosaminidasa/metabolismo; Interleucina-1beta; Osteoartritis/metabolismo; Vía de Señalización Wnt; Animales; Células Cultivadas; Técnicas de Silenciamiento del Gen; Humanos; Hialuronoglucosaminidasa/sangre; Hialuronoglucosaminidasa/genética; Masculino; Ratas Sprague-Dawley; Regulación hacia Arriba

Palabras clave

Cartilage degradation; Chondrocytes; Inflammatory responses; KIAA1199; Osteoarthritis; Wnt/ß-catenin signalling

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Cartílago Articular / Condrocitos / Interleucina-1beta / Vía de Señalización Wnt / Hialuronoglucosaminidasa Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2019 Tipo del documento: Article

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