Advanced Glycation End Products, a Potential Link between Psoriasis and Cardiovascular Disease: A Case-control Study.
Indian J Dermatol
; 64(3): 201-206, 2019.
Article
en En
| MEDLINE
| ID: mdl-31148858
ABSTRACT
CONTEXT Advanced glycation end products (AGEs) promote oxidative stress and inflammation by altering structure and function of proteins. They are excessively produced mainly in hyperglycemia, chronic inflammation and are involved in the development of atherosclerosis and cardiovascular disease. AIMS:
The aim of this study was to investigate whether skin AGEs levels were increased and had relation to premature atherosclerosis in patients with psoriasis. SUBJECTS ANDMETHODS:
Fifty-two psoriasis patients and 20 healthy controls (HC) were included. AGEs were determined by skin autofluorescence (SAF) analysis. High-sensitive C-reactive protein (hsCRP) and carotid intima-media thickness (CIMT) were also investigated. Physical activity and dietary patterns were determined. STATISTICAL ANALYSIS USED Fisher's exact test, two-sample t-tests, Mann-Whitney-U test, Pearson correlation, Spearman correlation, and Wilcoxon test.RESULTS:
SAFs were increased in psoriasis patients (1.8 arbitrary units [AUs]) compared to that in HC (1.6 AUs) (P = 0.057). Median CIMT values of HC and psoriasis groups were 0.43 (0.28-0.79), and 0.59 (0.44-0.98) respectively and the differences were significant (P = 0.001); hsCRP levels were not different between groups.CONCLUSIONS:
Skin AGE accumulation was found to have a correlation with CIMT in psoriasis patients providing evidence for the role of AGEs in premature atherosclerosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_doencas_nao_transmissiveis
/
1_doencas_transmissiveis
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2_muertes_prematuras_enfermedades_notrasmisibles
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Indian J Dermatol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Turquía