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The Innate Part of the Adaptive Immune System.
Hillion, Sophie; Arleevskaya, Marina I; Blanco, Patrick; Bordron, Anne; Brooks, Wesley H; Cesbron, Jean Yves; Kaveri, Srini; Vivier, Eric; Renaudineau, Yves.
Afiliación
  • Hillion S; UMR1227, Lymphocytes B et Autoimmunité, Univ Brest, Brest, France.
  • Arleevskaya MI; Laboratoire d'Immunologie et Immunothérapie, CHU de Brest, Brest, France.
  • Blanco P; Central Research Laboratory, Kazan Federal University, Kazan, Russia.
  • Bordron A; Laboratoire d'Immunologie et Immunogénétique, CHU Bordeaux, Bordeaux, France.
  • Brooks WH; UMR1227, Lymphocytes B et Autoimmunité, Univ Brest, Brest, France.
  • Cesbron JY; Department of Chemistry, University of South Florida, Tampa, FL, USA.
  • Kaveri S; Laboratoire d'Immunologie, CHU Grenoble Alpes, Grenoble, France.
  • Vivier E; INSERM, Université Paris Descartes, Sorbonne, Paris, France.
  • Renaudineau Y; INSERM, CNRS, Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Marseille, France.
Clin Rev Allergy Immunol ; 58(2): 151-154, 2020 Apr.
Article en En | MEDLINE | ID: mdl-31154567
ABSTRACT
The innate immune response provides a first line of defense against common microorganisms and, for more complex and/or recurring situations where pathogens must be eliminated, an adaptive immune response has emerged and evolved to provide better protection against subsequent infections. However, such dichotomy has to be reevaluated because innate B cells (e.g., B1 and marginal zone B cells) and the newly described innate lymphoid cells (iLC) have been found to exhibit innate-like properties, such as antigen internalization, regulatory B cell functions, and helper T cell activities. In addition, the production and function of natural antibodies (nAbs) by innate B cells and their capacity to activate the classical complement pathway constitute additional important mechanisms at the junction of innate and adaptive immunity as well as the recent integration of platelets into the innate immune spectrum. There is no doubt that these mechanisms present an advantage in immunity and homeostasis particularly during the first years of life, but arguments are arising to consider that these precursors may have detrimental effects in a variety of autoimmune/inflammatory diseases, allergies and cancers, as well as in response to immunotherapy. Accordingly, and as presented in this special issue of Clinical Reviews in Allergy and Immunology, a better comprehension of the key molecular and cellular actors implicated at the crossroads of the innate and adaptive immune response represents a new challenge in our understanding of the immunological and immunopathological responses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunidad Adaptativa / Sistema Inmunológico / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: Clin Rev Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunidad Adaptativa / Sistema Inmunológico / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: Clin Rev Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Francia
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