Total Synthesis of Clavosolideâ
A via Asymmetric Alcohol-Mediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction.
Angew Chem Int Ed Engl
; 58(31): 10718-10722, 2019 07 29.
Article
en En
| MEDLINE
| ID: mdl-31166641
ABSTRACT
The 20-membered marine macrodiolide clavosolideâ
A is prepared in 7 steps (LLS) in the absence of protecting groups or chiral auxiliaries via enantioselective alcohol-mediated carbonyl addition. In 9 prior total syntheses, 11-34 steps (LLS) were required.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Macrólidos
/
Alcoholes
/
Compuestos Alílicos
/
Policétidos
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos