Overcoming Treatment Toxicity through Sequential Therapy.

Benada, Jan; Ejlertsen, Bent; Sørensen, Claus Storgaard

Benada, Jan; Ejlertsen, Bent; Sørensen, Claus Storgaard.

Afiliación

Benada J; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
Ejlertsen B; Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen O, Denmark.
Sørensen CS; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address: claus.storgaard@bric.ku.dk.

Cancer Cell ; 35(6): 821-822, 2019 06 10.

Article en En | MEDLINE | ID: mdl-31185206

ABSTRACT

ABSTRACT

Combined inhibitions of PARP and DNA damage checkpoint have the potential for high anti-cancer efficacy, but concurrent inhibitions have been hampered by intolerable side effects. In this issue of Cancer Cell, Fang and colleagues (Fang et al., 2019) propose that sequential inhibitions of PARP and DNA damage checkpoint considerably widen the therapeutic window.

Asunto(s)

Neoplasias; Inhibidores de Poli(ADP-Ribosa) Polimerasas; Puntos de Control del Ciclo Celular; Proteínas de Ciclo Celular; Humanos; Proteínas Nucleares; Proteínas Tirosina Quinasas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Poli(ADP-Ribosa) Polimerasas / Neoplasias Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Dinamarca

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