Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.

Taylor, D Lansing; Gough, Albert; Schurdak, Mark E; Vernetti, Lawrence; Chennubhotla, Chakra S; Lefever, Daniel; Pei, Fen; Faeder, James R; Lezon, Timothy R; Stern, Andrew M; Bahar, Ivet

Taylor, D Lansing; Gough, Albert; Schurdak, Mark E; Vernetti, Lawrence; Chennubhotla, Chakra S; Lefever, Daniel; Pei, Fen; Faeder, James R; Lezon, Timothy R; Stern, Andrew M; Bahar, Ivet.

Afiliación

Taylor DL; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA. dltaylor@pitt.edu.
Gough A; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA. dltaylor@pitt.edu.
Schurdak ME; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.
Vernetti L; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Chennubhotla CS; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.
Lefever D; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Pei F; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.
Faeder JR; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Lezon TR; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.
Stern AM; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Bahar I; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.

Handb Exp Pharmacol ; 260: 327-367, 2019.

Article en En | MEDLINE | ID: mdl-31201557

Asunto(s)

Biología Computacional; Farmacología/tendencias; Biología de Sistemas; Animales; Sistemas de Liberación de Medicamentos; Descubrimiento de Drogas; Humanos; Modelos Animales; Modelos Biológicos; Células Madre

Palabras clave

Computational models of ADME-Tox; Computational models of disease; DILI; Drug development; Drug discovery; Drug repurposing; Induced pluripotent stem cells; Microphysiology systems; Omics analyses; PBPK; Personalized medicine; Quantitative systems pharmacology; Toxicology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacología / Biología Computacional / Biología de Sistemas Límite: Animals / Humans Idioma: En Revista: Handb Exp Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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