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Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh).
Veerman, Christiaan C; Mengarelli, Isabella; Koopman, Charlotte D; Wilders, Ronald; van Amersfoorth, Shirley C; Bakker, Diane; Wolswinkel, Rianne; Hababa, Mariam; de Boer, Teun P; Guan, Kaomei; Milnes, James; Lodder, Elisabeth M; Bakkers, Jeroen; Verkerk, Arie O; Bezzina, Connie R.
Afiliación
  • Veerman CC; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.
  • Mengarelli I; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.
  • Koopman CD; Department of Medical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Wilders R; Hubrecht Institute, 3584 CT Utrecht, The Netherlands.
  • van Amersfoorth SC; Amsterdam UMC, University of Amsterdam, Department of Medical Biology, Heart Failure Research Center, 1105 AZ Amsterdam, The Netherlands.
  • Bakker D; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.
  • Wolswinkel R; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.
  • Hababa M; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.
  • de Boer TP; Hubrecht Institute, 3584 CT Utrecht, The Netherlands.
  • Guan K; Department of Medical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Milnes J; Department of Pharmacology and Toxicology, Technische Universität Dresden, 01062 Dresden, Germany.
  • Lodder EM; Xention Ltd, Cambridge CB22 3EG, UK.
  • Bakkers J; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.
  • Verkerk AO; Department of Medical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Bezzina CR; Hubrecht Institute, 3584 CT Utrecht, The Netherlands.
Dis Model Mech ; 12(7)2019 07 09.
Article en En | MEDLINE | ID: mdl-31208990
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Bradicardia / Canales de Potasio / Acetilcolina / Receptores Colinérgicos / Subunidades beta de la Proteína de Unión al GTP Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Bradicardia / Canales de Potasio / Acetilcolina / Receptores Colinérgicos / Subunidades beta de la Proteína de Unión al GTP Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos