Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.
Mol Cell Oncol
; 6(4): 1610324, 2019.
Article
en En
| MEDLINE
| ID: mdl-31211242
ABSTRACT
Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is required to promote NLRP3 inflammasome assembly. We further demonstrate that differential cleavage of gasdermin D (GSDMD) by apoptotic caspases regulates inflammatory cell lysis. Here, we discuss our findings and perspectives for future studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suiza