Short-term effect on growth of two doses of GRF 1-44 in children with growth hormone deficiency: comparison with growth induced by methionyl-GH administration.
Horm Res
; 27(4): 181-9, 1987.
Article
en En
| MEDLINE
| ID: mdl-3125098
ABSTRACT
In a double-blind study 12 prepubertal children with idiopathic growth hormone (GH) deficiency were treated with growth hormone releasing factor (GRF) 1-44 in a dosage of 7.5 or 15 micrograms/kg body weight, administered once a day subcutaneously. With 7.5 micrograms/kg the average growth velocity increased from 2.5 to 4.6 cm/year, an insufficient response. With the higher dosage the average growth velocity increased from 2.7 to 7.0 cm/year, a similar increase as observed with GH therapy in subsequent periods. In 3 of the 6 children treated with the higher dose appropriate catch-up growth was observed. The growth response of the lower leg length was not always consistent with the statural growth response.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona del Crecimiento
/
Hormona Liberadora de Hormona del Crecimiento
/
Trastornos del Crecimiento
/
Hormonas
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Horm Res
Año:
1987
Tipo del documento:
Article
País de afiliación:
Países Bajos