Nuclear Phosphoinositides-Versatile Regulators of Genome Functions.
Cells
; 8(7)2019 06 28.
Article
en En
| MEDLINE
| ID: mdl-31261688
ABSTRACT
The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2's role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets-recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide-protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN Polimerasa I
/
ARN Polimerasa II
/
Núcleo Celular
/
Genoma
/
Fosfatidilinositol 4,5-Difosfato
/
Eucariontes
Idioma:
En
Revista:
Cells
Año:
2019
Tipo del documento:
Article
País de afiliación:
República Checa